Director of rugby Chris Boyd has made two changes to his starting XV as the Saints welcome Harlequins for their first home clash of the season.
Ken Pisi is promoted to the wing from the replacements bench, while flanker James Haskell is named in the back-row after being forced to withdraw with injury from last week’s opener at Gloucester.
Saints will be hoping to build on a strong recent home record after winning three of their final five home league matches last season, and they have not been defeated at Franklin’s Gardens by Quins for almost six years.
Alex Waller will once again skipper the side from loosehead prop, with James Fish and Ben Franks alongside him in the front-row.
Fit-again Haskell is the only change to the pack that started last week’s clash at Kingsholm, with Heinrich Brüssow and Teimana Harrison joining him at the base of the scrum, and David Ribbans completing the return to play protocols after an HIA last week to partner Courtney Lawes in the engine room.
Dan Biggar and Cobus Reinach remain in the half-back positions, while Piers Francis – who notched a try last week at Kingsholm – and Luther Burrell will continue to marshal Saints’ midfield.
Pisi comes into the back three, but full-back Ahsee Tuala and wing Tom Collins remain to round off the largely unchanged side.
However there are two more changes to the replacements, with Andy Symons and Harry Mallinder both impressing in Northampton Wanderers’ Premiership Rugby Shield clash on Monday, and earning their spots on the bench.
Meanwhile, Chris Robshaw leads a strong Harlequins side with four changes to the starting XV from last week.
In the scrum there are first starts of the season for Ben Glynn, Archie White and James Chisholm while Charlie Walker will play on the right wing.