Maria Sharapova is out of the US Open after she was beaten 6-4 6-3 by Carla Suarez Navarro in the fourth round.
The five-time Grand Slam champion was broken three times in the first set and immediately at the start of the second.
Sharapova broke back in the third but dropped serve again before squandering two break points while trailing 4-2.
The 2006 champion was then broken in the final game of the match as 30th seed Suarez Navarro celebrated her 30th birthday with a shock victory.
The Spaniard, who also reached the Australian Open quarter-final this year, will face last year’s runner-up Madison Keys next.
Russian 22nd seed Sharapova has not gone beyond the quarter-final stage of a Grand Slam since she returned from a 15-month doping ban in April last year.